Vitamin K Antagonist e.g. warfarin and other coumarins
Major bleed(s) are associated with one or more of the following factors:
• Hemodynamic instability
• Occurring at a critical site (see Quick Reference for full list of Critical Site Bleeds)
• Decrease of hemoglobin ≥ 2 g/dL (when baseline is known) or requiring transfusion of ≥ 2 units of packed RBCs.
Nonmajor bleeds are clinically relevant but do not meet the criteria for a major bleed.
Critical site bleeds compromise an organ's function. See Critical Site Bleed table in the Quick Reference section.
