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For the Hypertriglyceridemia app:This app assumes that the patient is currently taking or has attempted to take guideline-directed LDL-C–lowering therapies including statin and nonstatin agents.
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Categories
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Conditions and Medications Contributing to Hypertriglyceridemia |
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*Caveats: Triglyceride-raising medications require careful monitoring; minimizing other conditions that raise triglycerides; and, when clinically appropriate, using alternatives. | |
Diseases
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Diet/Lifestyle
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Drugs*
(Medications)
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Disorders of
Metabolism
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TG < 500 mg/dL
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TG 500-999 mg/dL
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TG > 1,000 mg/dL*
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Patients Messages
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*Nutrition resources for patients are available from the National Lipid Association: https://www.lipid.org/sites/default/files/when_your_tgs_are_over_1000_mgdl.pdf and https://www.learnyourlipids.com/heart-healthy-resources/fcs-cookbook/
† One serving of fruit =1 small piece of fruit (apple, orange, pear) or 1/2 cup chopped. ‡ Recommendations are based on a 2,000-calorie diet § Examples include a patient with diabetes or obesity. For these individuals, fewer servings may be indicated. Clinicians may opt to reduce total fat as percent of calories in some of these patients to 10%-15% (examples include those with a history of pancreatitis or those at the higher end of this range). MCT=medium-chain triglycerides; SFA=saturated fatty acids; TG=triglycerides. |
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Alcohol
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Restrict
Do not exceed limits: 2 drinks/d for men, 1 drink/d for women |
Abstain completely
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Abstain completely
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For patients with TG < 500 mg/dL, if alcohol is consumed, wine or beer with lower alcohol content is recommended over beverages with higher alcohol content. Alcohol content is listed on packaging and patients are encouraged to select beverages with lower alcohol content should they choose to consume alcohol
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Sugar-sweetened beverages
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Restrict
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Abstain completely
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Abstain completely
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Recommend plain or sparkling water, unsweetened tea, or coffee |
Fruits †
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Okay to include but individualize 3-4 servings/d
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Limit to 3 or 4 servings/d and individualize. Avoid fruits with a high glycemic index (ie, pineapple, mangoes, watermelon, ripe bananas)
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Limit to 1 serving/d. Recommend individualized medical nutrition therapy with a registered dietitian nutritionist.
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Consume whole fruit and avoid fruit juices when possible. Emphasize fresh fruits without added sugar or salt |
Vegetables
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Emphasize vegetables
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Emphasize vegetables, but avoid vegetables with a high glycemic index (ie, carrots, potatoes, sweet potatoes, yams, parsnips)
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Abstain completely
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Avoid canned vegetables with salt and vegetables frozen with sauces. Avoid vegetable juices. Recommend 2.5 cups/d ‡
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Legumes (beans, lentils, chickpeas, tofu, and so on)
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Emphasize
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Emphasize
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Emphasize
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Avoid added salt. Emphasize plant-based proteins instead of red meat. Avoid ultraprocessed meat alternatives
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Fish/Seafood
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Emphasize fatty fish
Recommend at least 2 servings/wk |
Emphasize either fatty or lean fish
Recommend 2 (or more) servings/wk |
Emphasize lean fish
Recommend 2 (or more) servings/wk |
Examples of fatty fish include salmon, farmed rainbow trout, and tuna. Examples of lean fish or seafood include cod, tilapia, haddock, flounder, and shrimp. Prioritize fresh, frozen, or packaged without sodium
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Poultry/lean meats
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Encourage
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Encourage
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Limit to the very leanest meats
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Substitute poultry and lean meats in place of red meat. Avoid processed meats
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Dairy products
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Limit full-fat dairy products. Avoid sugar-sweetened dairy products
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Limit full-fat dairy products. Avoid sugar-sweetened dairy products
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Eliminate full-fat dairy products and sugar-sweetened dairy products/div>
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Consume fat-free dairy products. Avoid any dairy products with added sugars
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Fiber-rich whole grains
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Emphasize 6 servings/d unless a lower-carbohydrate diet is indicated§
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Emphasize 4-6 servings/d unless a lower-carbohydrate diet is indicated§
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Emphasize individualized medical nutrition therapy with a registered dietician nutritionist
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Replace refined grains (white bread, white rice, pasta) with fiber-rich whole-grain cereals, bread, brown rice
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Nuts and peanuts
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Emphasize
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Consume in moderation
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Limit
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Preferably plain without added sugars or sodium
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Total fat
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Moderate fat (30%-35% of calories)
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Low fat (20%-25% of calories)
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Very-low fat (10%-15% of calories or less)
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Emphasize liquid oils (soybean, canola, corn, olive) instead of solid fats, butter, lard, and tropical oils (coconut, palm, and palm kernel)
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Cholesterol
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Choosing healthy protein foods, dairy products, and fats will limit cholesterol
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Choosing healthy protein foods, dairy products, and fats will limit cholesterol
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Choosing healthy protein foods, dairy products, and fats will limit cholesterol
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Desserts (sweets, cookies, cakes, pies, other pastries, ice cream, candy)
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Occasional indulgence
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Occasional indulgence
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Abstain completely
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Added sugars (table sugar, jams/jellies, honey)
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Occasional indulgence (<6% of calories)
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Occasional indulgence (<5% of calories)
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Abstain completely/eliminate
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Implement shared decision-making
intervention
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TG < 500 mg/dL | TG 500-999 mg/dL | TG ≥ 1000 mg/dL | |
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RDN = registered dietician nutritionist; TG = triglycerides †RDN referral advised ‡RDN referral necessary §Clinicians may opt to reduce total fat as percent of calories in some of these patients to 10% - 15% (examples include those with a history of pancreatitis or those at the higher end of this range). ‖Although clinicians should aim for their patients to meet the guideline-recommended goals for physical activity, any amount of physical activity is likely beneficial in sedentary individuals and should therefore be encouraged to reduce cardiometabolic risk. |
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Added sugar (percent calories)
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< 6%
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< 5%
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Eliminate
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Total fat (percent calories)
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30%-35%
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20%-25%
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10%-15%
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Alcohol
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Restrict
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Abstain completely
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Abstain completely
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Aerobic activity
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At least 150 min/wk of
accumulated
moderate-intensity or 75
min/wk of vigorous-intensity
aerobic physical activity(or
equivalent combination of
both)
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Weight loss (percent body weight)
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Recommended weight loss
goal is 5%-10% for all
patients with elevated TG
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Screening Questions for Assessing
Effects of Lifestyle on
Triglycerides
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• How often do you consume
sugar-sweetened beverages (soft
drinks, fruit drinks, sweet tea, or
sports/energy drinks)?
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• Do you consume sweets (pastries,
desserts, or candy?) If so, how much
and how often?
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• Do you drink alcoholic beverages
(beer, wine, or spirits)? If so, how
much and how often?
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• How often do
you consume foods that are deep
fried or high in saturated fats (ie,
butter, coconut, and other tropical
oils, full-fat dairy products, or
fatty red meat) as well as pizza?
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• Have you gained weight in the past year? If so, how much weight have you gained?
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• What do you do for physical activity? How often?
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Clinician Messages to Patients to Encourage Healthy Lifestyle Behaviors
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• Instead of drinking sugar-sweetened beverages, try a no-calorie sparkling water with a lemon slice.
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• Instead of eating a pastry, dessert, or candy, have fresh fruit or a small piece of dark chocolate.
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• Do you drink alcoholic beverages
(beer, wine, or spirits)? If so, how
much and how often?
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• If you are ready to lose weight, follow a healthy weight loss diet that achieves a slow, steady (and sustained) weight loss instead of a fad diet.
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• Increase your activity level by incorporating short walks in your daily life instead of being sedentary. Carry small weights on your walks.
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• Take small steps to increase your physical activity by parking the car at the end of a parking lot instead of close to the door, take the stairs rather than the elevator, and stand more during the day.
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*Recommendations for a healthy dietary pattern emphasize: vegetables; fruits; legumes; whole grains; nuts; and fish/seafood (other healthy proteins such as low-fat dairy, low-fat poultry); liquid plant-based oils; and replacing saturated fatty acids with monounsaturated fatty acids and polyunsaturated fatty acids. Recommendations also emphasize limiting: red and processed meats; refined carbohydrates; adding sugars (sweets and sugar-sweetened beverages); sodium and dietary cholesterol; and avoiding trans fats.